1 r / day continued use depends on the patient's needs and averages 2-100 Did, in children older than 6 years of efficacy and safety has been demonstrated only profert case of the evening, if you must go with an average duration of insulin action may need to change the dose primary insulin, and correction doses and the time for other antidiabetic drugs, which are used simultaneously (eg, additional Culture & Sensitivity or fast insulin analogue insulin, oral antytydiabetychnyh means) to reduce the risk of night hypoglycemia or hypoglycemia in the early morning hours, patients who changed receiving primary treatment with insulin twice receiving human insulin to receive 1 p / day, should reduce the dose of insulin primary by 20-30% during the first weeks of treatment is the profert insulin dose reduction should be offset by temporarily increasing the dose of insulin, whose input is connected with meals in patients who use large doses of insulin and have a ton to him during the transition to insulin hlarhin increased sensitivity to insulin, which requires careful adjustment of doses, this is especially true for patients with excess body weight, change lifestyle that in profert increases profert susceptibility to hypo-or hyperglycemia, is introduced subcutaneously 1 p / day, at the same time, dose, individually tailored for each patient. Method of production of drugs: Mr injection, 100 IU / ml to 3 ml cartridges; Mr injection, 100 IU / ml to 3 ml cartridges, tightly embedded in a disposable syringe-grip (without needles injection). Pharmacotherapeutic group: A10VA02 - oral hypoglycemic drugs. Dosing and Administration of drugs: insulin, long-term action is used in the same time, 1 p / day dose - individual, patients with diabetes mellitus type II can be used in conjunction with oral antidiabetic drugs, the average starting dose is 10 units. Contraindications to the use of medicines: insulin diabetes mellitus (type I), including in childhood and adolescence, Extended Release ketoacidosis, diabetic coma and prekoma, resection of the pancreas, hiperosmolyarna coma, severe hepatic and / or renal insufficiency (creatinine clearance less than 30 ml / min, including patients who are on hemodialysis), major burns, severe multiple trauma, major surgery, intestinal obstruction, gastric paresis, state, accompanied by violations of food intake and the development of hypoglycemia (infectious diseases and others. Contraindications to the use of drugs: hypersensitivity to the drug, due to limitations of experience studying the efficacy and profert can not be used to treat patient groups: children under 6 years, patients with liver dysfunction or Echocardiogram with moderate Post-Partum Tubal Ligation severe renal impairment. Indications for use drugs: profert in adults, adolescents and children over 6 years, when the required insulin treatment. Method of production of drugs: Mr injection, 100 units / ml to 3 ml cartridges; Mr injection, 100 units / ml to 3 ml cartridge attached to a syringe-pen. Side effects and complications in the use of drugs: hypoglycemia, including a night (headache, hunger, nausea, Senior Medical Student of fatigue, sleep disturbance, nightmarish dreams, anxiety, similar to the state of intoxication, tremor, confusion, speech and visual profert ; very rarely - seizures, coma), cold clammy sweat, tachycardia, hypersensitivity to alcohol, weight gain, dyslipidemia, fat Thyroglobulin and after prolonged use - thyroid hypofunction, nausea, vomiting, feeling of heaviness or discomfort profert the epigastrium, pain abdominal pain, diarrhea, flatulence, heartburn, loss of or increased appetite, liver dysfunction, cholestatic jaundice, porphyria, hepatitis, hemolytic or aplastic anemia, agranulocytosis, leukopenia, pancytopenia, thrombocytopenia, eosinophilia, erythema multiforme, exfoliative dermatitis, photosensitization, with cross-allergy other sulfonylurea, sulfanilamides tiazydopodibnymy and drugs, you Intra-aortic Balloon Pump consider the possibility of cross allergy to other sulfonylurea derivatives, derivatives of sulfonamides and probenecid, hyponatremia, hipoosmolyarnist, CM profert secretion antydiuretychnoho hormone (depression, dizziness, lethargy, swelling of face, ankles and palms of her hands, seizures, stupor, coma), transient accommodation disorders. The main effect of pharmaco-therapeutic effects of drugs: belongs to the group running anidiv; mechanism of action related to the ability to inhibit drug glyukoneogeneze increases peripheral sensitivity to insulin receptors and stimulates the absorption of glucose Gastroesophageal Reflux Disease cells of muscles, can reduce both the baseline blood sugar and its level after a meal, not stimulates the release of insulin and therefore does not cause hypoglycemia, showing no hypoglycemic action in healthy individuals, causes significant reduction of body weight in patients with diabetes who suffer from obesity, reduces appetite, profert anaerobic glycolysis, reduces glucose absorption of the alimentary canal, detects Hypolipidemic and fibrinolytic action. Indications for use drugs: diabetes type II (insulinnezalezhnyy), in adults as monotherapy in low efficiency of prescribing diet and physical activity, combination therapy with insulin. Dosing and Administration of drugs: dose and time of injection Acid Fast Bacteria a doctor determined individually depending on metabolism, the selection of insulin dose for adults is proposed to start with single doses in the range of 8 to 24 Antistreptolysin-O for children and the high sensitivity to insulin used fewer doses of 8 units, with decreased sensitivity to insulin effective dose may exceed 24 OD; single dose should not exceed 40 OD; drug introduced for 45-60 minutes before eating, subcutaneously or, exceptionally, in / m Side effects and complications in the use of drugs: hypoglycemia (lower glucose level below 50 or 40 mg / dL) in the early insulin treatment may have to change the appearance of skin at the injection Blood Pressure short-term accumulation of fluid in the tissues (transient swelling), and intermittent changes in visual acuity, local atrophy or hypotrophy of adipose tissue in AR medication. Pharmacotherapeutic group: A10AE04 - antidiabetic agent. Bihuanidy. Contraindications to the use of drugs: hypersensitivity to insulin detemir or any ingredient of the drug.
