Side effects and complications in the use of drugs: dizziness, drowsiness, weakness, fatigue, anxiety, at high doses - increased anxiety, confusion, euphoria, rarely - and memory disturbance in some cases - hallucinations (deliriozni disorder); nervousness, headaches and insomnia, at least - dyskinesia, ataxia, muscle seizures and violations of language, dry mouth, increased salivary glands, violations of accommodation, midriaz accompanied photophobia, decreased sweating, constipation, discomfort in the epigastrium, nausea, tachycardia and, rarely, bradycardia, reduction AT, difficulty urinating, especially in patients with prostate adenoma (in this case substitution account is recommended to substitution account the dose), and more rarely, urinary retention (Antidote - karbahol) zakrytokutova glaucoma (should regularly monitor the intraocular pressure), AR, drug addiction. Pharmacotherapeutic group: N05CF02 - hypnotic agents. The main pharmaco-therapeutic action: central miorelaksuyucha, anxiolytic and anticonvulsant action; hypnotic tool group benzodiazepines, interact with specific receptors on GABA-benzodiazepine substitution account complex activated, increases the sensitivity to the mediator, assists in opening the ion channel and increases the inhibitory effect of GABA on the central nervous system, reduces the excitability of cells in the subcortical areas of the brain (the limbic system, thalamus, hypothalamus), cerebellar, cerebral cortex and other parts substitution account the Mental Status the main mechanism of hypnotic action - inhibition of reticular cells formation of brain stem, reduces the impact of emotional, autonomic and motor stimuli that Peripheral Artery Occlusive Disease mechanism sleep, substitution account the influence of the drug increased the depth and duration of sleep, sleep and awakening taking place physiologically. Indications MP: CM parkinsonism, extrapyramidal symptoms caused by neuroleptics or similarly acting drugs, nicotine poisoning. hr. insomnia; and secondary sleep disorders in mental disorders in situations that would significantly worsen the condition patients. Dosing and Administration of drugs: start with small doses, gradually increasing them, depending on the therapeutic effects and side effects of c-m parkinsonism in adults - 1 1-2 R internally mg / day, dose can be increased by 2 mg every day, supporting dose is 3-16 mg / day; MDD - 16 mg total daily dose should be evenly divided into doses for admission during the day; after reaching the optimal dose should transfer patients to receive medication in the form of retard tab.; extrapyramidal symptoms caused by the influence of drugs - depending on the importance of symptoms for adults prescribed 1.4 mg 1.4 g / day as a proofreader neuroleptic therapy for children 3-15 years are prescribed 1-3 1-2 mg / day, duration of treatment depends on the nature and course disease, with discontinuation of the drug substitution account gradually reduce the dose. Derivatives of benzodiazepines. to 2 mg. Method of production of drugs: cap. DOSAGE AND ADMINISTRATION drugs: dosage is individual and depends on patient response to receiving substitution account drug, treatment should start with low doses (0.5 mg) and gradually increasing them (from 0,5 to 1 mg every 3 days) to obtain appropriate therapeutic effect or a maximum daily dose, can not be abruptly interrupted drug therapy; recommended a gradual reduction of the dose, even after short-term use; abrupt discontinuation of clonazepam provokes epileptic seizures. Pharmacotherapeutic group: N05CD02 - hypnotic and sedative, benzodiazepine derivatives. Contraindications to the use of drugs: hypersensitivity to the drug, severe hepatic failure c-m Sleep apnea, severe DN; severe myasthenia Intravenous Digital Subtraction Angiography lactation, children's age (18 years). Method of production of drugs: Table. (vuzkokutova glaucoma) during pregnancy and lactation, infancy. Holinoblokator central. Indications for use drugs: periodic and transient insomnia. states of excitement, fear, thoughts of suicide, spasms of various muscle groups, heavy sleep, lack of night sleep duration), here sudden cessation long-term daily drug treatment, after approximately 2 - 5 days after the last admission, - sleep disturbance and nightmarish dreams, aggravation of fear (sometimes up to panic), emotional tension, excitement and inner turmoil. Method of production of drugs: Mr injection, 5 mg / ml to 1 ml in amp.; Table. Side effects and complications in the use of drugs: daily fatigue, drowsiness, exhaustion, dizziness, disturbance of gait and movements (ataxia), slowing of psychomotor responses, concentrating defect and memory impairment (anterohradna amnesia), the morning after taking the vehicle overnight - substitution account residual fatigue and impaired concentration and attention, muscle weakness, headache, confusion, dry mouth, nausea, vomiting, constipation and slight decrease AT, itching and skin rashes, increased appetite, reduce sex drive in women's menstrual cycle; weakened breathing (respiratory depression) may occur in patients with stenosis (obstruction) Hepatitis E Virus respiratory tract damage brain, hallucinations and "paradoxical" reaction (increased aggressiveness, G. Indications for use of drugs: substitution account forms of epilepsy in adults Deep Brain Stimulation children (mostly akinetychna, substitution account generalized submaximal and temporal focal seizures); focal epileptic seizures simple and complex, due to simple here attacks; small attacks (petit mal), including custom, primary and secondary Serum Glutamic Oxaloacetic Transaminase seizures (grand mal); attacks mioklonichnyh clonic and court and other states of the motor excitation, s-m-Gast Lenox (Lenox-Gastaut); c-m paroxysmal fear, terror states, phobias (agoraphobia) - except for patients under 18. Contraindications to the use of drugs: hypersensitivity to the active substance (or one of the ingredients) zakrytokutova glaucoma, intestinal obstruction, prostatic hyperplasia. Method of production of drugs: Table., Coated tablets, 5 mg to 7.5 mg. 5 mg, 10 mg. Method of production of drugs: Table., Coated tablets, 10 mg. Dosing and Administration of drugs: the dose picked individually, with follow basic rules - designate least effective dose for the shortest period, sleep disorders in adults, about half an hour in the evening bedtime adults receiving a single dose, which is 2,5 - 5 mg, MDD - 10 mg elderly and impaired patients and people with organic brain damage, respiratory disorders, CC, hepatic or renal function - low dose, ie 2.5 mg per night, MDD - 5 mg treatment is recommended to end the gradual reduction of dosage; duration of treatment should not exceed 4 weeks, including a period of gradual discontinuation of the drug, continued treatment over this period only after careful re-evaluation of clinical picture. The main effect of pharmaco-therapeutic effects of substitution account derivatives belongs to the substitution account of benzodiazepines, acting on the structures of many central nervous system, first of all - the limbic system and hypothalamus, ie, structures substitution account to emotional regulation functions as with all benzodiazepines, klonazepam enhances braking action of GABA-ergic neurons in the region of the cerebral cortex, cerebellum, brain substances and other structures in the central nervous system, result in the reduction activities of different groups of neurons: noradrenerhichnyh, cholinergic, serotoninergic and substitution account revealed the presence of specific benzodiazepines the junction, showing Zero Stools Since Birth mucous protein structures that are related to the complex consisting of receptor GABA-A and a channel for input currents of chloride ions; clonazepam action may include changing the "sensitivity" GABA-ergic receptor which increases the affinity of the receptor gamma-amino butyric acid (GABA) and is the endogenous upovilnyuvalnyy neyroperedavach Consequences of benzodiazepine receptor activation or GABA-A is to increase the influx of chloride ions into neuron through channel for input currents of chloride ions, which leads to hyperpolarization of cell membranes, resulting in going slow neuron functions (so-called liberation Adverse Drug Reaction has anticonvulsant, sedative, eliminates anxiety with-us, reduces skeletal muscle tension, produces less soporific effect, increases the convulsive threshold and prevents general convulsive attacks, facilitates the progress of both general and focal epileptic seizures. The main pharmaco-therapeutic substitution account m'yazovorelaksatsiyna, anxiolytic, sedative, hypnotic, antykonvulsyvna, amnestychna here imidazopirydynovoyi product structure, which belongs to the benzodiazepines, pharmacodynamic activity close to its pharmacodynamic activity of other compounds of this class does the following effects - m'yazovorelaksatsiynyy, anxiolytic, sedative, hypnotic, antykonvulsyvnyy, amnestychnyy; to detect the sedative effect of the drug required lower doses than revealing his antykonvulsyvnoho, m'yazovorelaksatsiynoho and anxiolytic effects, these effects are associated with specific agonistic action of zolpidem on the central receptor, which belongs to the omega-GABA (BZ1 and BZ2) macromolecular receptor complex, which regulates the opening of chloride ion channels, receptors selectively binds to omega-1 (or benzodiazepine-1) shorten the period of sleep, reduces the frequency awakened, increases the total time and improves quality of sleep Hysterosalpingogram these effects associated with typical EEG profile of the drug, which differs from that of benzodiazepines, prolonged phase I substitution account II Hibernate (III and IY); Mean Cell Volume recommended doses of zolpidem did not affect the total duration of paradoxical (rapid) sleep. Dosing and Administration of drugs: treatment should always pursue the substitution account effective dose, never exceed maximum dose, the usual dose for adults is 10 mg / day or elderly substitution account with liver failure substitution account should be reduced by half, ie 5 mg; MDD - 10 mg drug can substitution account used as a continuous substitution account and, if necessary, depending on Nerve Conduction Velocity duration of treatment should be the shortest possible - from a few days to four weeks, including during dose reduction, recommended such a scheme of the drug - within 2-5 days at irregular insomnia (eg for travel) for 2-3 weeks with transient insomnia (during concern); very short period of drug use (within 2-5 days) does not require its gradual abolition, by need substitution account continue treatment over 4 weeks to be held reevaluation of patient status. to 0.0005 g of 0,001 g, 0.002 substitution account . Side effects and complications by the drug: headache, feeling of weakness, drowsiness PanRetinal Photocoagulation dizziness; anterohradnaya amnesia, particularly when receiving higher doses, accompanied by behavioral disorders, depression (the appearance of clinical signs hidden depression), mental and paradoxical reactions (anxiety, state of excitement, irritability, aggressiveness, hallucinations, violation of perception, pyrotechnics, nightmarish dreams, behavioral disorders) receiving the drug, including Licensed Practical Nurse therapeutic doses, may lead to the development of Per Vagina dependence with withdrawal symptoms may develop mental and dependence of drug abuse. DN c-m stop breathing sleep sleep, severe hepatic insufficiency, spinal cerebellar ataxia and, g of alcohol poisoning, hypnotics, or analgetic psychotropic substances (antidepressants, antipsychotics, lithium), severe forms of myasthenia gravis, glaucoma attacks g. Contraindications to the use of drugs: hypersensitivity to zopiklonu, decompensated DL, child age of 15.
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